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“抗暑一号”对热应激小鼠部分血液生理生化指标的影响

标题: “抗暑一号”对热应激小鼠部分血液生理生化指标的影响
英文标题: Effect of "Kangshuyihao" on Some Physiological and Biochemical Indexes of Blood in Heat Stress Mice
作者: 焦玉兰,翟超,史万玉,秦建华,包永占,钟秀会,赵玉龙
英文作者: JIAO Yu-lan1,ZHAI Chao2,SHI Wan-yu1,QIN Jian-hua1,BAO Yong-zhan1,ZHONG Xiu-hui1,ZHAO Yu-long3 (1.College of Animal Science and Technology,Hebei Agricultural University,Baoding,Hebei,071000,China,2.College of Environmental Science,Hebei University,Baoding,Hebei,071001,China,3.College of Animal Science and Technology,Shihezi University,Shihezi,Xinjiang,832000,China)
出版时间: 2009-07-20
机构: 河北农业大学动物科技学院,河北大学,新疆石河子大学动物科技学院
关键词: 中药复方制剂,热应激,血液生理生化指标,小鼠
英文关键词: traditional Chinese medicine,heat stress,physiological and biochemical indexes of blood,mouse
刊名: 动物医学进展
英文刊名: 动物医学进展
ISSN: 1007-5038
期号: 07
国内刊号: 61-1306/S
基金: 国家“十一五”科技支撑计划(2006BAD04A10-4);; 河北省重大技术创新专项计划项目(07227146Z-4)
主题: “抗暑一号”对热应激小鼠部分血液生理生化指标的影响
页码: 33-36
分类号: S853.7;
出版单位: 动物医学进展
数据来源: CNKI,WanFang
是否SCI: false
是否EI: false
是否核心: true
摘要: 为探讨中药复方制剂"抗暑一号"对热应激小鼠部分血液生理生化指标的影响,将50只昆明小鼠随机分成5组,每组10只,其中1组至3组为热应激中药低、中、高剂量治疗组,4组为阳性对照组,5组为阴性对照组。各组按常规饲养,其中1组至4组模拟夏季高温天气,在生化培养箱内复制热应激病理模型。1组至3组分别灌服1∶1的"抗暑一号"煎剂0.2、0.40、.6 mL,4组和5组分别灌服生理盐水0.4 mL,各组连续灌胃1周。各组于末次灌药后的24 h,摘除眼球采血分离血清检测相关生化指标。结果表明,阳性对照组中的K+、Cl-、GOT、GPT浓度较阴性对照组显著升高(P<0.01),而Na+、TP、ALB、AKP浓度较阴性对照组显著降低(P<0.01)。3个剂量均能不同程度改善热应激小鼠的血液生理生化指标异常,与阳性对照组相比,差异均极显著(P<0.01),其中Na+、K+、TP、GPT浓度已回升至正常水平(与阴性对照组相比,P>0.05)。
英文摘要: In order to investigate the effects of the traditional Chinese medicine compound "Kangshuyihao"on some physiological and biochemical indexes of blood in heat stress mice,50 Kunming mice were randomly divided into five groups.The groups 1-3 were treated with the low,middle,high doses "Kangshuyihao" respectively,the group 4 as positive control,the group 5 as negative control.The mice were given access to normal feed and water.The mice in groups 1-4 were made heat stress models by simulating high temperature in biochemical incubator.0.2,0.4,0.6 mL 1∶1 "Kangshuyihao" decoction were given to the mice in groups 1-3 respectively.The mice in groups 4-5 received an oral gavage of 0.4 mL normal saline.All mice were medicated successively for 7 days.The blood were collected by removing the eyeball,the sera were separated for detecting correlated indexes.The results indicated that:K+,Cl-,GOT,GPT concentrations in positive control group were increased significantly than those in negative control group(P<0.01),but Na+,TP,ALB,AKP concentrations in positive control group were decreased significantly than those in negative control group(P<0.01).All the three doses of "Kangshuyihao"could improve the physiological and biochemical indexes of blood in heat stress mice,compared with the mice in positive control group,the effects were significant(P<0.01).Na+,K+,TP,GPT concentrations could restore to the normal level.