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川楝素对妊娠小鼠子宫组织中CD4~+/CD8~+T细胞和F4/80~+巨噬细胞的影响

标题: 川楝素对妊娠小鼠子宫组织中CD4~+/CD8~+T细胞和F4/80~+巨噬细胞的影响
英文标题: Effects of Toosendanin on Contents of CD4~+,CD8~+ T Lymphocytes and F4/80~+ Macrophage in Uterus of Pregnant mice
作者: 张建楼,黄军,钟秀会
出版时间: 2011-01-01
机构: 河北农业大学
关键词: 川楝素,CD4 T淋巴细胞,CD8 T淋巴细胞,F4/80 巨噬细胞
英文关键词: toosendanin,CD4 lymphocyte,CD8 lymphocyte,F4/80 macrophage
刊名: 动物医学进展
英文刊名: Progress in Veterinary Medicine
ISSN: 1007-5038
卷号: 003
基金: ^A国家自然科学基金^B30270980;30571361^D1
页码: 86-90
分类号: R285.5
摘要: 为探讨CD4+、CD8+ T淋巴细胞和F4/80+巨噬细胞在流产发生机制中的意义,研究中药单体成分川楝素诱导小鼠流产的作用及机理,本试验给妊娠5 d小鼠连续3 d腹腔注射不同剂量的川楝素溶液,对照组以等量的蒸馏水代替,于妊娠9 d处死.在给药后发现随着注射川楝素剂量的增加,小鼠的流产率逐渐上升,CD4+、CD8+ T淋巴细胞和F4/80+巨噬细胞数量显著增加,CD4+/CD8+ T细胞比值上升,与对照组比较,差异显著(P<0.05).表明川楝素诱导小鼠妊娠失败与大量免疫细胞侵入子宫有密切关系.
英文摘要: The experiment was conducted to explore the abortion effect and mechanism induced by Chinese herbal medicine component toosendanin,and study the T CD4+,CD8+ T lymphocytes and F4/80+ macrophages in the significance of abortion mechanism.The pregnant mice were injected intraperitoneaslly by different doses of toosendanin at day 5,6,7.CD4+,CD8+ T lymphocytes and F4/80+ macrophages were tested by immunohistochemistry.The data suggested that injection of toosendain could gradually increase the mice''s abortion ra...