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菊苣酸的胃肠道稳定性研究

标题: 菊苣酸的胃肠道稳定性研究
英文标题: On Stability of Cichoric Acid in Gastrointestinal Tract
作者: 王庚南,王建平,宋娇,徐瑞涛,刘静,何欣
出版时间: 2013-01-01
机构: 河北农业大学
关键词: 菊苣酸,稳定性,胃肠道内容物
英文关键词: Cichoric acid, Stability, Digestive fluid
刊名: 安徽农业科学
英文刊名: Journal of Anhui Agricultural Sciences
ISSN: 0517-6611
期号: 41
卷号: 029
基金: ^A河北农业大学青年科学基金^B(QJ201220)^D1
页码: 11640-11641
分类号: S567.2
摘要: [目的]研究天然药物紫锥菊中菊苣酸在胃肠道环境下的稳定性.[方法]选择不同pH溶液与大鼠胃肠道内容物溶液,采用HPLC.uV方法,检测菊苣酸在各种溶液中的含量变化.[结果]经过4h的孵育,大鼠大肠内容物和小肠内容物对菊苣酸无显著影响(P〉0.05),而菊苣酸在胃内容物中的降解率为36%.在不同的pH环境中,菊苣酸相对稳定.[结论]菊苣酸在不同pH条件及小肠、大肠内容物中相对稳定,而在胃中有一定程度的降解,推测酶类可能是引起其降解的主要原因.
英文摘要: [ Objective ] To investigate the stability of cichoric acid in gastrointestinal tract. [ Method ] Under different pH value and rat diges- tive fluid, the quantification of cichoric acid was determined by a sensitive HPLC - UV method. [ Result] After 4 h incubation, the large and small gut digestive fluid of rats have no significant effects on cichoric acid, the degradation rate of cichoric acid in digestive fluid is 36%. The cichoric acid is relatively stable under different pH value. [ Conclusion] Compared with the two results, it presented that the drug was stable in the chemical (pH) conditions, small intestine and colon, but unstable in the stomach caused by the enzymes.