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异香豆素噁二唑类化合物的合成及除草活性

标题: 异香豆素噁二唑类化合物的合成及除草活性
英文标题: Synthesis and herbicidal activity of several substituted isocoumarin oxadiazole
作者: 时佳妹,霍静倩,张哲,张金林
英文作者: SHI Jiamei,HUO Jingqian,ZHANG Zhe,ZHANG Jinlin,College of Plant Protection, Agricultural University of Hebei
出版时间: 2016-08-09
机构: 河北农业大学植物保护学院
关键词: 异香豆素,噁二唑,合成,除草活性
英文关键词: isocoumarin,oxadiazole,synthesis,herbicidal activity
刊名: 农药学学报
英文刊名: Chinese Journal of Pesticide Science
ISSN: 1008-7303
期号: 04
卷号: v.18
国内刊号: 11-3995/S
基金: 国家自然科学基金资助项目(31171877)
主题: 异香豆素噁二唑类化合物的合成及除草活性
页码: 129-133
分类号: TQ457.2
出版单位: 农药学学报
是否SCI: 0
是否EI: 0
是否核心: 0
摘要: 为了寻找具有较高除草活性的异香豆素类化合物,设计合成了16个新型异香豆素噁二唑类化合物4a~4p,其结构均经核磁共振氢谱、碳谱及高分辨质谱确证。初步除草活性测定结果表明,部分目标化合物在500 mg/L下对马唐Digitaria sanguinalis L.和反枝苋Amaranthus retroflexus L.具有一定的除草活性,其中化合物4j(4-[5-(4-氯-苯基)-[1,2,4]噁二唑-3-基]-3-己基-6,7-二甲氧基异香豆素)的活性最好,对马唐和反枝苋的致死率分别为64%和62%。
英文摘要: In order to get a series of isocoumarin compounds with high herbicidal activity, 16 substituted oxadiazole 4a-4p were synthesized. All the target compounds were characterized by1 H NMR, 13 C NMR and HRMS. Preliminary screening with Digitaria sanguinalis L. and Amaranthus retroflexus L. demonstrated that some of the target compounds exhibited herbicidal activity at the concentrations of 500 mg/L. 4j, 4-(5-(4-chlorophenyl)-1, 2, 4-oxadiazol-3-yl)-3-hexyl-6, 7-dimethoxy-1H-isochromen-1-one had the best effect to D. sanguinalis and A. retroflexus of which the mortality rates were 64% and 62%.